• Active Learning to Classify Macromolecular Structures in situ for Less Supervision in Cryo-Electron Tomography

    6 days ago - By Oxford Journals

    AbstractMotivationCryo-Electron Tomography is a 3D bioimaging tool that visualizes the structural and spatial organization of macromolecules at a near-native state in single cells, which has broad applications in life science. However, the systematic structural recognition and recovery of macromolecules captured by cryo-ET are difficult due to high structural complexity and imaging limits. Deep learning based subtomogram classification have played critical roles for such tasks. As supervised approaches, however, their performance relies on sufficient and laborious annotation on a large...
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