• Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer

    1 month ago - By Wiley

    Abstract
    Biologics manufacturing is capital and consumable intensive with need for advanced inventory planning to account for supply chain constraints. Early-stage process design and technology transfer are often challenging due to limited information on process variability regarding bioreactor titer, process yield, and product quality. Monte Carlo methods offer a stochastic modeling approach for process optimization where probabilities of occurrence for process inputs are incorporated into a deterministic model to simulate more likely scenarios for process outputs. In this study, we...
    Read more ...