• PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

    14 days ago - By Genome Biology

    We propose a new computational framework, probabilistic transcriptome-wide association study , to investigate causal relationships between gene expressions and complex traits. PTWAS applies the establis...
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  • Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

    14 days ago - By Genome Biology

    To provide a comprehensive mechanistic interpretation of how known trait-associated SNPs affect complex traits, we propose a method, Primo, for integrative analysis of GWAS summary statistics with multiple set...
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