• A quantitative model for metabolic intervention using gut microbes

    3 days ago - By Wiley

    Abstract
    As medicine shifts toward precision‐based and personalized therapeutics, utilizing more complex biomolecules to treat increasingly difficult and rare conditions, microorganisms provide an avenue for realizing the production and processing necessary for novel drug pipelines. More so, probiotic microbes can be co‐opted to deliver therapeutics by oral administration as living drugs, able to survive and safely transit the digestive tract. As living therapeutics are in their nascency, traditional pharmacokinetic‐pharmacodynamic models for evaluating drug candidates are not appropriate...
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