• Mucin tuning

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00849-9 Mucin tuning
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  • Picking off persisters

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00847-x Picking off persisters
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  • A molecular shape-shifter

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00848-w A molecular shape-shifter
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  • Central dogma, redefined

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00850-2 Central dogma, redefined
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  • Untying knots with force

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00856-w RNA knot-like structures function as an efficient physical barrier to RNA exoribonucleases. Single-molecule mechanical manipulation is used to unfold these structures and unravel the cause of their unusual mechanical resistance from a different direction.
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  • Prospecting for natural products by genome mining and microcrystal electron diffraction

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00834-2 Combined use of microcrystal electron diffraction and genome mining for biosynthetic gene clusters enables the rapid structural elucidation of natural products, including a newly discovered 2-pyridone compound and a revised structure of fischerin.
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  • Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

    1 month ago - By ACS Division of Biological Chemistry

    Nature Chemical Biology, Published online: 26 July 2021; doi:10.1038/s41589-021-00836-0 A survey of natural metabolic pathways for C1 substrates (methane, methanol, carbon dioxide, and carbon monoxide) highlights past efforts and recent progress, and informs future opportunities to create synthetic C1-utilizing microbes.
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