• The Properties of Ion Channels Formed in Bilayer Lipid Membranes by Amphotericin and N-Methyl Derivative of Amphotericin under Their Action on One Side

    25 days ago - By Springer

    Abstract
    It was found that the modification of one side of lipid membranes by amphotericin B and N‑methyl derivatives of amphotericin B resulted in a discrete increase in the membrane conductivity by the channel mechanism. The conditions under which amphotericin B increased the conductivity of membranes upon addition on one side of the membranes were found. The effect of amphotericin B upon addition on one side of the membranes was observed in an acidic medium and at a two-fold lower concentration of phospholipids in the membrane-forming solution. A large dispersion of the conductivity...
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