• Structural Significance of Conformational Preferences and Ribose-Ring-Puckering of Hyper Modified Nucleotide 5'-Monophosphate 2-Methylthio Cyclic N6-Threonylcarbamoyladenosine Present at 37th Position in Anticodon Loop of tRNALys

    3 monthes ago - By Springer

    Abstract
    Structural significance of conformational preferences and ribose ring puckering of newly discovered hyper modified nucleotide, 5'-monophosphate 2-methylthio cyclic N 6 -threonylcarbamoyladenosine have been investigated using quantum chemical semi-empirical RM1 and molecular dynamics simulation techniques. Automated geometry optimization of most stable structure of p-ms 2 ct 6 A has also been carried out with the help of abinitio as well as semi empirical quantum chemical methods. Most stable structure of p-ms 2 ct 6 A is stabilized by intramolecular interactions between N(3)...HC...
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