• An Ensemble Method to Reconstruct Gene Regulatory Networks Based on Multivariate Adaptive Regression Splines

    14 days ago - By IEEE/ACM

    Gene regulatory networks play a key role in biological processes. However, GRNs are diverse under different biological conditions. Reconstructing gene regulatory networks from gene expression has become an important opportunity and challenge in the past decades. Although there are a lot of existing methods to infer the topology of GRNs, such as mutual information, random forest, and partial least squares, the accuracy is still low due to the noise and high dimension of the expression data. In this paper, we introduce an ensemble Multivariate Adaptive Regression Splines based method to...
    Read more ...