• Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system

    1 month ago - By Oxford Journals

    AbstractMotivationTranscriptional surges generated by two-component systems have been observed experimentally in various bacteria. Suppression of the transcriptional surge may reduce the activity, virulence, and drug resistance of bacteria. In order to investigate the general mechanisms, we use a PhoP/PhoQ TCS as a model system to derive a comprehensive mathematical modeling that governs the surge. PhoP is a response regulator, which serves as a transcription factor under a phosphorylation-dependent modulation by PhoQ, a histidine kinase.ResultsOur model reveals two major signaling...
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  • Comparison of various electricity market pricing strategies to reduce generation cost of a microgrid system using hybrid WOA-SCA

    1 month ago - By Springer

    Abstract
    This paper aims to minimize the generation cost of a low voltage grid-connected microgrid system using a novel hybrid whale optimization algorithm - Sine cosine algorithm optimization technique. Three different methods of electricity market prices are formulated in turns and the generation cost is evaluated for each method to sort out the best among them which yields the least generation cost of the same microgrid system. Both active and passive participation of grid are studied to acknowledge its importance. Numerical results show that the time of usage method of electricity...
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