• Using prior knowledge in the inference of gene association networks

    28 days ago - By Springer

    Abstract
    Traditional computational techniques are recently being improved with the use of prior biological knowledge from open-access repositories in the area of gene expression data analysis. In this work, we propose the use of prior knowledge as heuristic in an inference method of gene-gene associations from gene expression profiles. In this paper, we use Gene Ontology, which is an open-access ontology where genes are annotated using their biological functionality, as a source of prior knowledge together with a gene pairwise Gene-Ontology-based measure. The performance of our proposal...
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