• In vitro activity of a panel of per- and polyfluoroalkyl substances , fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor alpha, PPAR gamma, and estrogen receptor assays

    1 day ago - By Indigo Biosciences

    ABSTRACT Data demonstrate numerous per- and polyfluoroalkyl substances activate peroxisome proliferator-activated receptor alpha , however, additional work is needed to characterize PFAS activity on PPAR gamma and other nuclear receptors. We utilized in vitro assays with either human or rat PPARα or PPARγ ligand binding domains to evaluate 16 PFAS (HFPO-DA, HFPO-DA-AS, NBP2,
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