• SHARPIN: Role in Finding NEMO and in Amyloid-Beta Clearance and Degradation Pathway in Alzheimer's Disease?

    1 month ago - By Springer

    Abstract
    SHANK- associated RH domain-interacting protein is a multifunctional protein associated with numerous physiological functions and many diseases. The primary role of the protein as a LUBAC-dependent component in regulating the activation of the transcription factor NF-κB accounts to its role in inflammation and antiapoptosis. Hence, an alteration of SHARPIN expression or genetic mutations or polymorphisms leads to the alteration of the above-mentioned primary physiological functions contributing to inflammation-associated diseases and cancer, respectively. However, there are...
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