• A distinct ssDNA/RNA binding interface in the Nsp9 protein from SARS‐CoV‐2

    13 days ago - By Wiley

    Abstract
    Severe acute respiratory syndrome coronavirus 2 is a novel, highly infectious RNA virus that belongs to the coronavirus family. Replication of the viral genome is a fundamental step in the virus life cycle and SARS-CoV-2 non-structural protein 9 is shown to be essential for virus replication through its ability to bind RNA in the closely related SARS-CoV-1 strain. Two recent studies revealing the three-dimensional structure of Nsp9 from SARS-CoV-2 have demonstrated a high degree of similarity between Nsp9 proteins within the coronavirus family. However, the binding affinity to RNA...
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