• Cover Image, Volume 89, Issue 12

    1 month ago - By Wiley

    Reverse Cover: The cover image is based on the review Critical assessment of methods of protein structure prediction - Round XIV by Andriy Kryshtafovych, Torsten Schwede, Maya Topf, Krzysztof Fidelis and John Moult, DOI 10.1002/prot.26237. The highlight of the CASP14 experiment was an outstanding performance of AlphaFold2 structure modeling method. The cover image shows the backbone agreement with experiment of the best models in CASP1 (1994), CASP5 (2002) and the latest three CASP experiments. The data are shown as linear trend lines; for the most recent round, individual target points...
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  • Cover Image, Volume 89, Issue 12

    Cover Image, Volume 89, Issue 12

    1 month ago - By Wiley

    Front Cover: The cover image has been created by Clemens Meyer and Adam Cain from DeepMind. It shows the ground truth experimental structure for CASP14 target T1044 in green, together with the prediction of the AlphaFold2 team in blue.Target T1044 is the RNA polymerase of the crAss-like phage phi14:2, a large single-chain protein with 2180 residues. Its structure was published by Drobysheva et al.. Target T1044 was split into 9 domains for the CASP14 experiment (T1031, T1033, T1035, T1037, T1039, T1040, T1041, T1042, and T1043); a prediction for the full protein chain, including domain...
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