• Highly stable peptide adducts from hard keratins as biomarkers to verify local sulfur mustard exposure of hair by high-resolution mass spectrometry

    10 days ago - By Springer

    Abstract
    In the recent past, the blister agent sulfur mustard deployed by the terroristic group Islamic State has caused a huge number of civilian and military casualties in armed conflicts in the Middle East. The vaporized or aerolized agent might be inhaled and have direct contact to skin and hair. Reaction products of SM with plasma proteins represent well-established systemic targets for the bioanalytical verification of exposure. The SM-derived hydroxyethylthioethyl -moiety is attached to nucleophilic amino acid side chains and allows unambiguous adduct detection. For shipping of...
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