• HiSCF: leveraging higher-order structures for clustering analysis in biological networks

    13 days ago - By Oxford Journals

    AbstractMotivationClustering analysis in a biological network is to group biological entities into functional modules, thus providing valuable insight into the understanding of complex biological systems. Existing clustering techniques make use of lower-order connectivity patterns at the level of individual biological entities and their connections, but few of them can take into account of higher-order connectivity patterns at the level of small network motifs.ResultsHere, we present a novel clustering framework, namely HiSCF, to identify functional modules based on the higher-order...
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