• Improving protein tertiary structure prediction by deep learning and distance prediction in CASP14

    7 days ago - By Wiley

    Abstract
    Substantial progresses in protein structure prediction have been made by utilizing deep-learning and residue-residue distance prediction since CASP13. Inspired by the advances, we improve our CASP14 MULTICOM protein structure prediction system by incorporating three new components: (1) a new deep learning-based protein inter-residue distance predictor to improve template-free tertiary structure prediction, (2) an enhanced template-based tertiary structure prediction method, and (3) distance-based model quality assessment methods empowered by deep learning. In the 2020 CASP14...
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