• MicroRNA-381-3p Confers Protection Against Ischemic Stroke Through Promoting Angiogenesis and Inhibiting Inflammation by Suppressing Cebpb and Map3k8

    14 days ago - By Springer

    Abstract
    Ischemic stroke is a serious disease with limited prevention methods, and various genes and microRNAs have been found to be dysregulated in the pathogenesis of this disease. This study aims to explore the potential role of miR-381-3p in ischemic stroke, along with its underlying mechanism. A mouse model of ischemic stroke was developed using middle cerebral artery occlusion. Next, the expression of mitogen-activated protein kinase kinase kinase 8 and CCAAT enhancer binding protein beta was determined by RT-qPCR. Gain- and loss-of-function approaches were applied to analyze the...
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