• New Amino Acid Substitution Matrix Brings Sequence Alignments into Agreement with Structure Matches

    1 month ago - By Wiley

    Abstract
    Protein sequence matching presently fails to identify many structures that are highly similar, even when they are known to have the same function. The high packing densities in globular proteins lead to interdependent substitutions, which have not previously been considered for amino acid similarities. At present, sequence matching compares sequences based only upon the similarities of single amino acids, ignoring the fact that in densely packed protein, there are additional conservative substitutions representing exchanges between two interacting amino acids, such as a...
    Read more ...