• Peakhood: individual site context extraction for CLIP-seq peak regions

    1 month ago - By Oxford Journals

    AbstractMotivationCLIP-seq is by far the most widely used method to determine transcriptome-wide binding sites of RNA-binding proteins. The binding site locations are identified from CLIP-seq read data by tools termed peak callers. Many RBPs bind to a spliced RNA context, but all currently available peak callers only consider and report the genomic context. To accurately model protein binding behavior, a tool is needed for the individual context assignment to CLIP-seq peak regions.ResultsHere we present Peakhood, the first tool that utilizes CLIP-seq peak regions identified by peak...
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