• PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry data

    1 month ago - By Oxford Journals

    AbstractSummaryWe present PrInCE, an R/Bioconductor package that employs a machine-learning approach to infer protein-protein interaction networks from co-fractionation mass spectrometry data. Previously distributed as a collection of Matlab scripts, our ground-up rewrite of this software package in an open-source language dramatically improves runtime and memory requirements. We describe several new features in the R implementation, including a test for the detection of co-eluting protein complexes and a method for differential network analysis. PrInCE is extensively documented and fully...
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