• PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A‐mediated cell cycle progression

    15 days ago - By Springer

    Abstract
    Background
    The roles of Polypyrimidine tract-binding protein 3 in regulating lung squamous cell carcinoma cells progression is unclear. The aim of this study was to investigate the role of PTBP3 in LUSC.
    Methods
    Expression and survival analysis of PTBP3 was firstly investigated using TCGA datasets. Quantitative reverse transcription PCR and Western blot were performed to detect PTBP3 expression in clinical samples. Moreover, cell counting kit 8 assays, colony formation assays and in vivo tumor formation assays were used to examine the effects of PTBP3 on LUSC cell proliferation...
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