• Study on the Correlation Between Regulatory Proteins of N6-methyladenosine and Oxidative Damage in Cadmium-induced Renal Injury

    13 days ago - By Springer

    Abstract
    As a common environmental heavy metal pollutant, cadmium has been well evidenced to cause kidney damage; yet, the underlying mechanisms are still not fully clarified. In this study, cell viability of human renal tubular epithelial cell was determined by CCK-8 assay after treatment with CdSO 4. Then, apoptotic morphology of cells was observed by Hoechst staining and level of reactive oxygen species was detected by fluorescent probes. Subsequently, mRNA levels of Nrf2, HO-1, m 6 A methyltransferases , m 6 A demethylases , m 6 A methyl-binding proteins were detected by real-time...
    Read more ...