• The Open Targets Post-GWAS analysis pipeline

    10 days ago - By Oxford Journals

    AbstractMotivationGenome-wide association studies are a powerful method to detect even weak associations between variants and phenotypes, however many of the identified associated variants are in non-coding regions, and presumably influence gene expression regulation. Identifying potential drug targets, i.e. causal protein-coding genes, therefore requires crossing the genetics results with functional data.ResultsWe present a novel data integration pipeline, that feeds into an interactive data resource, that analyses GWAS results in the light of experimental epigenetic and cis-regulatory...
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