• Thermodynamic modeling reveals widespread multivalent binding by RNA-binding proteins

    3 monthes ago - By Oxford Journals

    AbstractMotivationUnderstanding how proteins recognize their RNA targets is essential to elucidate regulatory processes in the cell. Many RNA-binding proteins form complexes or have multiple domains that allow them to bind to RNA in a multivalent, cooperative manner. They can thereby achieve higher specificity and affinity than proteins with a single RNA-binding domain. However, current approaches to de novo discovery of RNA binding motifs do not take multivalent binding into account.ResultsWe present Bipartite Motif Finder , which is based on a thermodynamic model of RBPs with two...
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