• Allogenic stem cell transplant-associated acute graft versus host disease: a computational drug discovery text mining approach using oral and gut microbiome signatures

    14 days ago - By Springer

    Abstract
    Purpose
    Acute graft versus host disease is a major cause of non-relapse morbidity and mortality post-allogenic hematopoietic stem cell transplant. Using conventional literature search and computational approaches, our objective was to identify oral and gut bacterial species associated with aGVHD, potentially affecting drug treatment via lipopolysaccharide pathways.
    Methods
    Medline, PubMed, PubMed Central, and Google Scholar were searched using MeSH terms. The top 100 hits per database were curated, and 25 research articles were selected to examine oral and gut microbiomes...
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