• Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device

    3 days ago - By Wiley

    ABSTRACT
    Assisted reproduction technologies for clinical and research purposes rely on a brief in vitro embryo culture which, despite decades of progress, remain suboptimal in comparison to the physiological environment. One promising tool to improve this technique is the development of bespoke microfluidic chambers. Here we present and validate a new microfluidic device in polydimethylsiloxane for the culture of early mouse embryos.
    Device material and design resulted embryo compatible and elicit minimal stress. Blastocyst formation, hatching, attachment and outgrowth formation on...
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