• NEAT1 Decreasing Suppresses Parkinson's Disease Progression via Acting as miR-1301-3p Sponge

    10 days ago - By Springer

    Abstract
    Long non-coding RNA plays a crucial role in multiple disorders, while the role of it in Parkinson's disease is still unclear. Here, the increased lncRNA NEAT1 was discovered in MPP + -induced SH-SY5Y cells. Then, we proved that NEAT1 decreasing suppressed MPP + -induced neuronal apoptosis, upregulation of α-syn and activation of NLRP3 inflammasome. Rescue experiments shown that the inhibition of NEAT1 decreasing to MPP + -induced activation of NLRP3 inflammasome and subsequent neuronal apoptosis can be reversed by overexpressed α-syn. Subsequently, we indicated the interaction...
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  • MiR-708 and miR-335-3p Inhibit the Apoptosis of Retinal Ganglion Cells Through Suppressing Autophagy

    10 days ago - By Springer

    Abstract
    This study aimed to clarify the regulation role of miR-708 and miR-335-3p in retinal ganglion cell autophagy and apoptosis in glaucoma. Chronic glaucoma mice were established by laser photocoagulation. RGCs were isolated and transfected with a series of plasmids and the cultured in 60 mmHg pressure. miR-335-3p, miR-708, and ATG3 mRNA expressions were detected by qRT-PCR. Protein levels of ATG3, autophagy-related protein LC3, and p62 were detected by Western blot. The apoptosis of RGCs was detected by flow cytometry. The regulation role of miR-335-3p/miR-708 in ATG3 was confirmed...
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