• A novel plant‐made monoclonal antibody enhances the synergetic potency of an antibody cocktail against the SARS‐CoV‐2 Omicron variant

    15 days ago - By Wiley

    Summary
    Abstract
    This study describes a novel, neutralizing monoclonal antibody , 11D7, discovered by mouse immunization and hybridoma generation, against the parental Wuhan-Hu-1 RBD of SARS-CoV-2. We further developed this mAb into a chimeric human IgG and recombinantly expressed it in plants to produce a mAb with human-like, highly homogenous N-linked glycans that has potential to impart greater potency and safety as a therapeutic. The epitope of 11D7 was mapped by competitive binding with well characterized mAbs, suggesting that it is a Class 4 RBD-binding mAb that binds to the RBD...
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