• MicroRNA-425-5p modulates osteoporosis by targeting annexin A2

    1 month ago - By Springer

    Abstract
    Background
    Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells is an important mechanism of osteoporosis. The object of this study was to explore the role and mechanism of microRNA miR-425-5p in the differentiation of MSC.
    Methods
    The expression of miR-425-5p in MSC was detected by quantitative reverse transcriptase-polymerase chain reaction. Cell proliferation, cell cycle and apoptosis were detected by CCK-8 colorimetry and flow cytometry. The expression of TNF were detected by ELISA.
    Results
    Our data show that MiR-425-5p could...
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