• Normalized coefficient of variation : a method to evaluate circadian clock robustness in population scale data

    1 month ago - By Oxford Journals

    AbstractSummaryRobust oscillation of clock genes is a core feature of the circadian system. Relative amplitude measures the robustness of clock gene oscillations but only works for longitudinal samples. We lack a method for estimating robust oscillations from human samples without labeled time. We show that the normalized coefficient of variation of 10 clock genes is linearly correlated with their normalized rAMP, independent of time labels. We found that the mean nCV of clock genes are consistently decreased in tumors compared to non-tumors, suggesting a new therapeutic target in cancer...
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