• Physiochemical properties of enveloped viruses and arginine dictate inactivation

    5 days ago - By Wiley

    Abstract
    Background
    Therapeutic protein manufacturing would benefit by having an arsenal of ways to inactivate viruses. There have been many publications on the virus inactivation ability of arginine at pH 4.0, but the mechanism of this inactivation is unknown. This study explored how virus structure and solution conditions enhance virus inactivation by arginine and leads to a better understanding of the mechanism of virus inactivation by arginine.
    Results
    Large diameter viruses from the Herpesviridae family with loosely packed lipids were highly inactivated by arginine, whereas small...
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