• Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells

    1 month ago - By Springer

    Abstract
    Aims/hypothesis
    Diabetes mellitus causes a progressive loss of functional efficacy in stem cells, including cardiac progenitor cells. The underlying molecular mechanism is still not known. MicroRNAs are small, non-coding RNA molecules that regulate genes at the post-transcriptional level. We aimed to determine if diabetes mellitus induces dysregulation of miRNAs in CPCs and to test if in vitro therapeutic modulation of miRNAs would improve the functions of diabetic CPCs.
    Methods
    CPCs were isolated from a mouse model of type 2 diabetes , non-diabetic mice and human right atrial...
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