• High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3

    25 days ago - By IEEE/ACM

    SARS-CoV-2 encodes the Mac1 domain within the large nonstructural protein 3 , which has an ADP-ribosylhydrolase activity conserved in other coronaviruses. The enzymatic activity of Mac1 makes it an essential virulence factor for the pathogenicity of coronavirus. They have a regulatory role in counteracting host-mediated antiviral ADP-ribosylation, which is unique part of host response towards viral infections. Mac1 shows highly conserved residues in the binding pocket for the mono and poly ADP-ribose. Therefore, SARS-CoV-2 Mac1 enzyme is considered as an ideal drug target and inhibitors...
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  • AGTR2 , One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells

    25 days ago - By IEEE/ACM

    Recently, it was confirmed that ACE2 is the receptor of SARS-CoV-2, the pathogen causing the recent outbreak of severe pneumonia around the world. It is confused that ACE2 is widely expressed across a variety of organs and is expressed moderately but not highly in lung, which, however, is the major infected organ. Therefore, we hypothesized that there could be some other genes playing key roles in the entry of SARS-CoV-2 into human cells. Here we found that AGTR2 , a G-protein coupled receptor, has interaction with ACE2 and is highly expressed in lung with a high tissue specificity. More...
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  • Two SARS-CoV-2 strains cause independent infections only 19 days apart

    Two SARS-CoV-2 strains cause independent infections only 19 days apart

    25 days ago - By Bond Life Sciences Center

    Increasing detection of reinfections and rediscovering brand new infections within days raises concerns for herd immunity and the durability of vaccine efficacy.
    Cynthia Tang working to figure out how COVID-19 reinfections can bring us answers on how the virus is developing at Bond LSC. | photo by Davis Suppes, Bond LSC
    By Davis Suppes | Bond LSC
    Like many viruses, SARS-CoV-2 continues to develop and evolve with time. As the virus evolves it can become more infectious, produce worse symptoms, and have a higher fatality rate. While people receive more treatment for this virus we also learn...
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  • Relative synonymous codon usage of ORF1ab in SARS-CoV-2 and SARS-CoV

    25 days ago - By Springer

    Abstract
    Background
    COVID-19, as a novel coronavirus disease caused by new coronavirus SARS-CoV-2, spreads all over the world, and brings harm to human in many countries. Humans suffered a lot from both SARS-CoV-2 now and by SARS-CoV in the year 2003. It is important to understand the differences and the relationships between these two types of viruses.
    Objective
    To compare relative synonymous codon usage of ORF1ab gene in SARS-CoV-2 and SARS-CoV, relative synonymous codon usage of their genomes are studied in this paper from the bioinformatics perspective.
    Methods
    The ORF1ab gene, which...
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  • Watching SARS-CoV-2 spread in animal models in real time

    25 days ago - By ScienceDaily

    New 'reporter viruses' developed by researchers make it much easier to observe SARS-CoV-2 and its variants in cells and live animals in the lab, enabling faster screening of potential anti-viral drugs, vaccines and neutralizing antibodies.
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  • Evolution of the SARS‐CoV‐2 proteome in three dimensions during the first six months of the COVID‐19 pandemic

    25 days ago - By Wiley

    Abstract
    Understanding the molecular evolution of the SARS-CoV-2 virus as it continues to spread in communities around the globe is important for mitigation and future pandemic preparedness. Three-dimensional structures of SARS-CoV-2 and other coronaviral proteins archived in the Protein Data Bank were used to analyze viral proteome evolution during the first six months of the COVID-19 pandemic. Analyses of spatial locations, chemical properties, and structural and energetic impacts of the observed amino acid changes in > 48,000 viral isolates showed how each one of the 29 viral proteins...
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