• Quercetin‐loaded platelets as a potential targeted therapy for Glioblastoma Multiforme cell line U373‐MG

    25 days ago - By Wiley

    Abstract
    Over the globe, the incidence of glioblastoma multiforme is very low i.e., 1-4 cases per 100,000, but it is fatal and cancer grows very fast inside the brain tissues, namely astrocytes and oligodendrocytes. Because of the rapid growth, it is difficult to halt the dissemination of tumor in adjacent tissues. Although temozolomide is a currently approved standard of care, it develops resistance over the period. Therefore, there is a need to develop a novel drug delivery system. In this work, authors have developed platelets as drug delivery carriers-loaded with quercetin for...
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  • Global Solvability and Optimal Control to a Haptotaxis Cancer Invasion Model with Two Cancer Cell Species

    25 days ago - By Springer

    Abstract
    This paper deals with an optimal control problem for a haptotaxis model which describes two types of cancer cell invading the surrounding healthy tissue. Cancer cells can be treated by therapeutic agents considered as the control variable. Our primary goal is to characterize an optimal control which balances the therapeutic benefits with its side effects. Firstly, the global bounded weak solution of state system in spatial dimensions
    \ are obtained by using the Banach fixed-point theorem and a new iteration criterion of
    \ estimates as well as the adapted Moser-type iteration...
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