• Human Adipose Mesenchymal Stromal Cells growing into PCL‐nHA electrospun scaffolds undergo hypoxia adaptive ultrastructural changes

    1 day ago - By Wiley

    Abstract
    Human Adipose-Derived Mesenchymal Stem/Stromal Cells have great potential for tissue regeneration. Since transplanted hAD-MSCs are likely to be placed in a hypoxic environment, culturing the cells under hypoxic conditions might improve their post-transplantation survival and regenerative performance. The combination of hAD-MSCs and PCL-nHA nanofibers synergically improves the contribution of both components for osteoblast differentiation. In this work, we hypothesized that this biomaterial constitutes a hypoxic environment for hAD-MSCs. We studied the cellular re-arrangement and...
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