• Integrative Analysis of the Expression of microRNA, Long Noncoding RNA, and mRNA in Osteoarthritis and Construction of a Competing Endogenous Network

    29 days ago - By Springer

    Abstract
    This study aimed to identify potential core microRNAs , long noncoding RNAs , and mRNAs in osteoarthritis to construct a competing endogenous RNA and co-expression network. Differentially expressed miRNAs in the dataset GSE143514 comprising five OA and three normal tissues were identified using the DEseq package. Core miRNAs were identified as DEMis overlapping with those reported by the human microRNA disease database. LncRNAs were predicted by the miRNA-lncRNA interactions network from the encyclopedia of RNA interactomes. MiRNet and ENCORI were employed to predict the mRNAs...
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