• Immunoliposomes bearing lymphocyte activation gene 3 fusion protein and P5 peptide: A novel vaccine for breast cancer

    10 days ago - By Wiley

    Abstract
    LAG3‐Ig as an immune adjuvant has elicited potent anti‐tumor immune responses in several preclinical and clinical studies, but the full potential immunostimulatory of LAG3‐Ig has yet to be achieved. We hypothesized that by anchoring LAG3‐Ig to the surface of liposomes, the adjuvant activity of LAG3‐Ig could be improved. We also investigated the immunotherapy by co‐delivery of liposome‐coupled LAG3‐Ig and P5 tumor antigen in mice model of TUBO breast cancer. We prepared and characterized novel PEGylated liposomes bearing surface conjugated LAG3‐Ig and P5. Consistent with our...
    Read more ...