• Prefiltration enhances performance of sterile filtration for glycoconjugate vaccines

    9 days ago - By Wiley

    Abstract
    Recent studies have reported very low capacity during sterile filtration of glyconconjugate vaccines due to rapid fouling of the filter. The objective of this study was to explore the potential for significantly increasing the capacity of the sterile filter through the use of an appropriate prefilter. Data were obtained using prefilters with different pore size and chemistry, with the sterile filtration performed at constant filtrate flux using 0.22 μm Durapore® polyvinylidene difluoride membranes. Prefiltration through 5 μm pore size Durapore® or Nylon prefilters nearly...
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