BioTech Mag Search: Virus
Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV‐1 Infection
9 days ago - By Wiley
Preclinical evaluation of a novel transcription activator‐like effector nuclease to target the C‐C chemokine receptor type 5 locus. Up to 90% of CCR5 alleles are disrupted in primary CD4+ T cells without notable off‐target activity or impact on the potency of edited cells, paving their way for clinical application in hematopoietic stem and progenitor cells of HIV patients.
Abstract
Therapies to treat patients infected with human immunodeficiency virus aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell...
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
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A rarefaction-based extension of the LDM for testing presence-absence...
AbstractMotivationMany methods for testing association between the microbiome and covariates of interest (e.g., clinical outcomes, environmental factors) assume that these...
MBG: Minimizer-based Sparse de Bruijn Graph Construction
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VPF-Class: Taxonomic assignment and host prediction of uncultivated viruses...
AbstractMotivationTwo key steps in the analysis of uncultured viruses recovered from metagenomes are the taxonomic classification of the viral sequences and the identification...