• Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins

    14 days ago - By Wiley

    Abstract
    The Gag proteins of retroviruses play an essential role in virus particle assembly by forming a protein shell or capsid and thus generating the virion compartment. A variety of human proteins have now been identified with structural similarity to one or more of the major Gag domains. These human proteins are thought to have been evolved or “domesticated” from ancient integrations due to retroviral infections or retrotransposons. Here, we report that X-ray crystal structures of stably folded domains of MOAP1 and PEG10 are highly similar to the C-terminal capsid domains of cognate...
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