• Tuning the binding interface between Machupo virus glycoprotein and human transferrin receptor

    1 day ago - By Wiley

    Abstract
    Machupo virus, known to cause hemorrhagic fevers, enters human cells via binding with its envelope glycoprotein to transferrin receptor 1. Similarly, the receptor interactions have been explored in biotechnological applications as a molecular system to ferry therapeutics across the cellular membranes and through the impenetrable blood-brain barrier that effectively blocks any such delivery into the brain. Study of the experimental structure of Machupo virus glycoprotein 1 in complex with TfR and glycoprotein sequence homology has identified some residues at the interface that...
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