BioTech Mag Search: Protein
Fabrication of multifunctional metal-organic frameworks nanoparticles via layer-by-layer self-assembly to efficiently discover PSD95-nNOS uncouplers for stroke treatment
Disruption of the postsynaptic density protein-95 -neuronal nitric oxide synthase coupling is an effective way to treat ischemic stroke, however, it still faces some...
18 hours ago - Journal of Nanobiotechnology
Structural Models of Viral Insulin‐like Peptides and their Analogs
Abstract The insulin receptor , the insulin-like growth factor-1 receptor , and the insulin/IGF1 hybrid receptors are homologous transmembrane receptors. The peptide ligands...
1 day ago - Wiley
A TGF‐α and TGF‐β1 Poloxamer‐based micelle/hydrogel composite: A promising novel candidate for the treatment of anosmia
Abstract Anosmia is the inability to smell or loss of the sense of smell. It can reduce your ability to detect the smell of smoke, gas leaks, or spoiled food, as well as hinder...
1 day ago - Wiley
Tp0684, Tp0750, and Tp0792 Recombinant Proteins as Antigens for the Serodiagnosis of Syphilis
Abstract The incidence of syphilis has increased alarmingly over the years. Its diagnosis continues to be a challenge, leading to the search for new alternative and effective...
1 day ago - Springer
Long intergenic noncoding RNA LINC01287 drives the progression of cervical cancer via regulating miR-513a-5p/SERP1
Abstract Cervical cancer is one of the most frequent types of cancer in women, which is characterized by high invasion and metastatic tendency in its advanced stage. Emerging...
2 days ago - Springer - 2 articles
From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris
Expansion of the genetic code is a frequently employed approach for the modification of recombinant protein properties. It involves reassignment of a codon to another, e.g...
2 days ago - Microbial Cell Factories
GPT Language Model Spells Out New Proteins
Human languages have much in common with proteins, at least in terms of computational modeling. This has led research teams to apply novel methods from natural language...
2 days ago - IEEE Spectrum
Predicting Molecular Properties of α‐Synuclein Using Force Fields for Intrinsically Disordered Proteins
Abstract Independent force field validation is an essential practice to keep track of developments and for performing meaningful Molecular Dynamics simulations. In this work...
2 days ago - Wiley
CircWalk: a novel approach to predict CircRNA-disease association based on heterogeneous network representation learning
Several types of RNA in the cell are usually involved in biological processes with multiple functions. Coding RNAs code for proteins while non-coding RNAs regulate gene...
2 days ago - BMC Bioinformatics
Compact Genetic Algorithm-Based Feature Selection for Sequence-Based Prediction of Dengue-Human Protein Interactions
Dengue Virus infection is one of the rapidly spreading mosquito-borne viral infections in humans. Every year, around 50 million people get affected by DENV infection, resulting...
3 days ago - IEEE/ACM
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2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
2nd International Conference on Generic Drugs and Biosimilars
Scientist I - Shoreline Biosciences - San Diego, CA
To create safe, effective, and affordable immunotherapies for the treatment of seriously ill patients. This position will report directly to...
Identification of missing hierarchical relations in the vaccine ontology...
The Vaccine Ontology is a biomedical ontology that standardizes vaccine annotation. Errors in VO will affect a multitude of applications that it is being used in. Quality...
Metacells untangle large and complex single-cell transcriptome networks
Single-cell RNA sequencing technologies offer unique opportunities for exploring heterogeneous cell populations. However, in-depth single-cell transcriptomic characterization...
ARNAque: an evolutionary algorithm for inverse pseudoknotted RNA folding...
We study in this work the inverse folding problem for RNA, which is the discovery of sequences that fold into given target secondary structures.
Constructing the boundary between potent and ineffective siRNAs by...
In siRNA based antiviral therapeutics, selection of potent siRNAs is an indispensable step, but these commonly used features are unable to construct the boundary between potent...
Research Associate, Antibody Discovery & Engineering - Antibody Design Labs...
The responsibilities of the successful candidate include, but are not limited to, preparation of reagents and products, primer design, PCR, molecular cloning,... $24 - $34 an...
Scientist/Senior Scientist, Enzymology - Loxo Oncology - San Diego, CA
In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in...
Neural network methods for diagnosing patient conditions from...
Cardiopulmonary exercise testing provides a reliable and reproducible approach to measuring fitness in patients and diagnosing their health problems. However, the data from...
Low-intensity pulsed ultrasound/nanomechanical force generators enhance...
Low-intensity pulsed ultrasound has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy needs to be further optimized. Ultrasound in...
Immunotherapy for type 1 diabetes mellitus by adjuvant-free Schistosoma...
Type 1 diabetes mellitus is an autoimmune disease mediated by autoreactive T cells and dominated by Th1 response polarization. Insulin replacement therapy faces great...