• Microfluidic Chip‐Based Single‐Cell Cloning to Accelerate Biologic Production Timelines

    1 month ago - By Wiley

    Abstract
    Cell line development represents a critical, yet time-consuming step in the biomanufacturing process as significant resources are devoted to the scale-up and screening of several hundreds to thousands of single-cell clones. Typically, transfected pools are fully recovered from selection and characterized for growth, productivity, and product quality to identify the best pools suitable for single-cell cloning using limiting dilution or fluorescence activated cell sorting. Here we report the application of the Berkeley Lights Beacon Instrument in an early SCC process to accelerate...
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