• Quinacrine causes apoptosis in human cancer cell lines through caspase-mediated pathway and regulation of small-GTPase

    1 month ago - By Journal of Biosciences

    Abstract
    Quinacrine , an FDA-approved anti-malarial drug, has shown to have anticancer activities. Due to its ‘shotgun' nature, QC has become an inevitable candidate for combination chemotherapy. There is lack of study of the molecular interplay between colorectal cancer microenvironment and its metastasis. In this study, we focused on the differential anti-cancerous effect of QC on two different human cancer cell lines, HCT 116 and INT 407. Results suggest that cytotoxicity increased in both the cell lines with an increase in QC concentration. The expression patterns of small-GTPases and...
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