• PASSION: an ensemble neural network approach for identifying the binding sites of RBPs on circRNAs

    7 days ago - By Oxford Journals

    AbstractMotivationDifferent from traditional linear RNAs , circular RNAs are a special type of RNAs that have a closed ring structure. Accumulating evidence has indicated that circRNAs can directly bind proteins and participate in a myriad of different biological processes.ResultsFor identifying the interaction of circRNAs with 37 different types of circRNA-binding proteins, we develop an ensemble neural network, termed PASSION, which is based on the concatenated artificial neural network and hybrid deep neural network frameworks. Specifically, the input of the ANN is the optimal feature...
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