• T-Gene: Improved target gene prediction

    1 month ago - By Oxford Journals

    AbstractMotivationIdentifying the genes regulated by a given transcription factor is a key step in developing a comprehensive understanding of gene regulation. Previously we developed a method for predicting the target genes of a transcription factor based solely on the correlation between a histone modification at the TF's binding site and the expression of the gene across a set of tissues or cell lines. That approach is limited to organisms for which extensive histone and expression data is available, and does not explicitly incorporate the genomic distance between the TF and the...
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