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Journal of Biosciences

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  • By Journal of Biosciences   -   Jul 9, 2020

    SENSITIZATION OF HEPATOCELLULAR CARCINOMA CELLS TOWARDS DOXORUBICIN AND SORAFENIB IS FACILITATED BY GLUCOSE-DEPENDENT ALTERATIONS IN REACTIVE OXYGEN SPECIES, P-GLYCOPROTEIN AND DKK4

    Abstract Altered glucose uptake and metabolism is the key characteristic of cancer cells including hepatocellular carcinoma. However,...

    Drugs, Drug, Protein, Cancer
  • By Journal of Biosciences   -   Jul 9, 2020

    RE-EVALUATION OF THE PHYLOGENETIC RELATIONSHIPS AND SPECIES DELIMITATION OF TWO CLOSELY RELATED FAMILIES USING TWO DNA BARCODE MARKERS

    Abstract The families Lamiaceae and Verbenaceae comprise several closely related species that possess high morphological synapomorphic...

    General, Genes, Gene, DNA, Discovery
  • By Journal of Biosciences   -   Jul 2, 2020

    RECK AND TIMP-2 MEDIATE INHIBITION OF MMP-2 AND MMP-9 BY ANNONA MURICATA

    Abstract Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the...

    Tissue, Protein, Cancer
  • By Journal of Biosciences   -   Jul 2, 2020

    CARDIAC DIFFERENTIATION OF BONE-MARROW-RESIDENT C-KIT + STEM CELLS BY L-CARNITINE INCREASES THROUGH SECRETION OF VEGF, IL6, IGF-1, AND TGF-Β AS CLINICAL AGENTS IN CARDIAC REGENERATION

    Abstract The idea of regenerating lost myocardium via cell-based therapies remains as highly considerable. C-kit + stem/progenitor...

    Therapies, Genes, Gene, Clinical
  • By Journal of Biosciences   -   Jul 2, 2020

    PRIGSA2: IMPROVED VERSION OF PROTEIN REPEAT IDENTIFICATION BY GRAPH SPECTRAL ANALYSIS

    Abstract Tandemly repeated structural motifs in proteins form highly stable structural folds and provide multiple binding sites associated...

    Protein
  • By Journal of Biosciences   -   Jul 2, 2020

    MIRNA-MEDIATED REGULATION OF AUXIN SIGNALING PATHWAY DURING PLANT DEVELOPMENT AND STRESS RESPONSES

    Abstract Auxin is one of the most important plant growth hormones, playing a crucial role in development as well as in stress responses....

    Biosynthesis, Plants
  • By Journal of Biosciences   -   Jul 2, 2020

    HUMAN PLACENTAL LAMININ: ROLE IN NEURONAL DIFFERENTIATION, CELL ADHESION AND PROLIFERATION

    Abstract Human placental extract has wound healing potential. Immuno-blots revealed presence of laminin in placental extract. It was...

    Protein, Cellular, Heal
  • By Journal of Biosciences   -   Jul 2, 2020

    RECEPTORS INVOLVED IN DEXKETOPROFEN ANALGESIA IN MURINE VISCERAL PAIN

    Abstract Various animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs...

    Animals, Chemicals, Drugs, Chemical, Drug
  • By Journal of Biosciences   -   Jul 2, 2020

    ADVANCES IN GENE THERAPY FOR HEMOPHILIA

    Abstract Hemophilia is a hereditary disorder that can be life-threatening in individuals who have severe spontaneous bleeding resulting...

    Therapies, Gene Therapy, Genes, Gene
  • By Journal of Biosciences   -   Jul 2, 2020

    G604S-HERG MUTATION IN LQT2 LEADS TO AUTOPHAGY VIA THE UPR-RELATED PATHWAY

    Abstract Congenital long QT syndrome is a heart channel disease associated with fatal ventricular arrhythmias or cardiac arrest. Human...

    Protein, Gene, Genes
  • By Journal of Biosciences   -   Jun 29, 2020

    DRUG TARGETS FOR COVID-19 THERAPEUTICS: ONGOING GLOBAL EFFORTS

    Abstract The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to the...

    Virus, Drugs, Discovery, Drug, Therapeutics, Health
  • By Journal of Biosciences   -   Jun 23, 2020

    CHOLINE-BETAINE PATHWAY CONTRIBUTES TO HYPEROSMOTIC STRESS AND SUBSEQUENT LETHAL STRESS RESISTANCE IN PSEUDOMONAS PROTEGENS SN15-2

    Abstract Pseudomonas protegens SN15-2, a typical non-spore-forming rhizosphere bacterium, has excellent biocontrol capabilities; thus,...

    Bacterium, Environment, Genes, Gene
  • By Journal of Biosciences   -   Jun 23, 2020

    MITOCHONDRIAL REACTIVE OXYGEN SPECIES CAUSE MAJOR OXIDATIVE MITOCHONDRIAL DNA DAMAGES AND REPAIR PATHWAYS

    Abstract Mitochondria-derived reactive oxygen species are produced at a variety of sites and affect the function of bio-molecules....

    Neurology, DNA
  • By Journal of Biosciences   -   Jun 23, 2020

    GENETIC DIVERSITY ANALYSIS OF SPECIALTY GLUTINOUS AND LOW-AMYLOSE RICE LANDRACES OF ASSAM BASED ON WX LOCUS AND MICROSATELLITE DIVERSITY

    Abstract The sticky rice of Assam is traditionally classified as bora and chokuwa based on their stickiness after cooking. The Waxy...

    Polymorphisms, Genetics, Nucleotide, Genes, Gene, Nucleotides
  • By Journal of Biosciences   -   Jun 16, 2020

    COMPARATIVE STUDY OF THE SBP-BOX GENE FAMILY IN RICE SIBLINGS

    Abstract SBP-box genes are a class of plant-specific transcription factors which have a common DNA-binding domain with an unusual zinc-finger...

    Plants, Protein, Genome, DNA, Gene, Genomics, Genes
  • By Journal of Biosciences   -   Jun 12, 2020

    CURRENT GLOBAL VACCINE AND DRUG EFFORTS AGAINST COVID-19: PROS AND CONS OF BYPASSING ANIMAL TRIALS

    Abstract COVID-19 has become one of the biggest health concern, along with huge economic burden. With no clear remedies to treat the...

    Research, Protein, BioTech, Animals, Biotech, Clinical, Immunity, Health, Vaccine, Drug, Vaccines, Drugs
  • By Journal of Biosciences   -   Jun 11, 2020

    ELEVATED EXPRESSION OF STEMNESS GENES IN ADIPOSE-DERIVED MESENCHYMAL STEM CELLS CULTURED ON FIBRIN SCAFFOLD

    Abstract In regenerative medicine, MSCs need to be pluripotent for better results. In this study, the effect of fibrin scaffold on...

    Tissue, Protein, Medicine, Gene, Genes, Regenerative medicine
  • By Journal of Biosciences   -   Jun 9, 2020

    CRISPR-MEDIATED KNOCKDOWN OF MIR-214 MODULATES CELL FATE IN RESPONSE TO ANTI-CANCER DRUGS IN HPV-NEGATIVE AND HPV-POSITIVE CERVICAL CANCER CELLS

    Abstract Cervical cancer is the fourth most common cause of mortality in women worldwide. In this study we investigated the effect...

    Drugs, Drug, Cancer
  • By Journal of Biosciences   -   Jun 4, 2020

    MIR-17-5P MITIGATES ENDOMETRIOSIS BY DIRECTLY REGULATING VEGFA

    Abstract Endometriosis is a common disease in women, which impairs the quality of life in patients. Recently, accumulating evidences...

    Tissue, Protein
  • By Journal of Biosciences   -   Jun 4, 2020

    MUTATIONS IN SARS-COV-2 VIRAL RNA IDENTIFIED IN EASTERN INDIA: POSSIBLE IMPLICATIONS FOR THE ONGOING OUTBREAK IN INDIA AND IMPACT ON VIRAL STRUCTURE AND HOST SUSCEPTIBILITY

    Abstract Direct massively parallel sequencing of SARS-CoV-2 genome was undertaken from nasopharyngeal and oropharyngeal swab samples...

    Genomics, Genome, Protein, RNA