• By Wiley   -   Sep 29, 2020

    CONFORMATIONAL STABILITY OF THE BACTERIAL ADHESIN, FIMH, WITH AN INACTIVATING MUTATION

    Abstract Allostery governing two conformational states is one of the proposed mechanisms for catch‐bond behavior in adhesive proteins....

    Protein
  • By Wiley   -   Sep 28, 2020

    VIRUS RECOVERY BY TANGENTIAL FLOW FILTRATION: A MODEL TO GUIDE THE DESIGN OF A SAMPLE CONCENTRATION PROCESS

    Abstract A simple model is developed to describe the instantaneous and cumulative recovery of viruses from water during sample concentration...

    Virus
  • By Wiley   -   Sep 28, 2020

    GHARF16‐1 MODULATES LEAF DEVELOPMENT BY TRANSCRIPTIONALLY REGULATING THE GHKNOX2‐1 GENE IN COTTON

    Summary The leaf is a crucial organ evolved with remarkable morphological diversity to maximize plant photosynthesis. The leaf shape...

    Plants, Gene, Genes, Genetics
  • By Wiley   -   Sep 28, 2020

    MODELING TANGENTIAL FLOW FILTRATION USING REVERSE ASYMMETRIC MEMBRANES FOR BIOREACTOR HARVESTING

    Abstract Tangential flow filtration has many advantages for bioreactor harvesting as the permeate could be introduced directly to the...

    Feed
  • By Wiley   -   Sep 28, 2020

    TUNING MONOCLONAL ANTIBODY GALACTOSYLATION USING RAMAN SPECTROSCOPY‐CONTROLLED LACTIC ACID FEEDING

    Abstract A key aspect of large‐scale production of biotherapeutics is a well‐designed and consistently‐executed upstream cell culture...

    AIDS, Feed
  • By Wiley   -   Sep 28, 2020

    VIRUS RECOVERY BY TANGENTIAL FLOW FILTRATION: A MODEL TO GUIDE THE DESIGN OF A SAMPLE CONCENTRATION PROCESS

    Abstract A simple model is developed to describe the instantaneous and cumulative recovery of viruses from water during sample concentration...

    Virus
  • By Wiley   -   Sep 27, 2020

    THE DEGREE AND LENGTH OF O‐GLYCOSYLATION OF RECOMBINANT PROTEINS PRODUCED IN PICHIA PASTORIS DEPENDS ON THE NATURE OF THE PROTEIN AND THE PROCESS TYPE

    The methylotrophic yeast Pichia pastoris is known as an efficient host for the production of heterologous proteins. While N‐linked...

    Protein, Immunity, Nature
  • By Wiley   -   Sep 27, 2020

    PRODUCTION, PROCESSING AND CHARACTERIZATION OF SYNTHETIC AAV GENE THERAPY VECTORS

    Over the last two decades, gene therapy vectors based on wild‐type Adeno‐associated viruses are safe and efficacious in numerous clinical...

    Virus, Gene, Engineering, Clinical, Gene Therapy, Therapies, Immunity, Genes, Nature
  • By Wiley   -   Sep 27, 2020

    PSEUDOMONAS AS VERSATILE AROMATICS CELL FACTORY

    Background Aromatics and their derivatives are valuable chemicals with a plethora of important applications and thus play an integral...

    Microbes, BioTechnology, Biosynthesis, Environmental, Chemicals, Chemical, Feedstocks
  • By Wiley   -   Sep 26, 2020

    MULTIMODAL IMAGING AND SOFT X‐RAY TOMOGRAPHY OF FLUORESCENT NANODIAMONDS IN CANCER CELLS

    Multimodal imaging promises to revolutionize our understanding of biological processes across scales in space and time by combining...

    Biology, Biologic, Biological, Cancer, Chemicals, Chemical
  • By Wiley   -   Sep 26, 2020

    LOCALIZED SAMPLING ENABLES MONITORING OF CELL STATE VIA INLINE ELECTROSPRAY IONIZATION MASS SPECTROMETRY

    Nascent advanced therapies, including regenerative medicine and cell and gene therapies, rely on the production of cells in bioreactors...

    Therapies, Gene, Manufacturing, Medicine, Genes, Regenerative medicine
  • By Wiley   -   Sep 26, 2020

    RECONSTITUTION OF AN ANTI‐HER2 ANTIBODY PARATOPE BY GRAFTING DUAL CDR‐DERIVED PEPTIDES ONTO A SMALL PROTEIN SCAFFOLD

    Target‐binding small proteins are promising alternatives to conventional monoclonal antibodies , offering advantages in terms of tissue...

    Protein, Manufacturing, Computers, Tissue
  • By Wiley   -   Sep 25, 2020

    MODELING TANGENTIAL FLOW FILTRATION USING REVERSE ASYMMETRIC MEMBRANES FOR BIOREACTOR HARVESTING

    Abstract Tangential flow filtration has many advantages for bioreactor harvesting as the permeate could be introduced directly to the...

    Feed
  • By Wiley   -   Sep 25, 2020

    TUNING MONOCLONAL ANTIBODY GALACTOSYLATION USING RAMAN SPECTROSCOPY‐CONTROLLED LACTIC ACID FEEDING

    Abstract A key aspect of large‐scale production of biotherapeutics is a well‐designed and consistently‐executed upstream cell culture...

    AIDS, Feed
  • By Wiley   -   Sep 25, 2020

    EVALUATION OF THE SINGLE‐USE FIXED BED BIOREACTORS IN SCALABLE VIRUS PRODUCTION

    The accelerating development of gene therapy from research towards clinical trials and beyond has elevated the demand for practical...

    Virus, Research, Manufacturing, Therapies, Clinical, Gene, Genes, Gene Therapy
  • By Wiley   -   Sep 24, 2020

    FERTILITY RECOVERY OF WHEAT MALE STERILITY CONTROLLED BY MS2 USING CRISPR/CAS9

    Abstract Wheat is one of the most important cereal crops globally. It is essential to develop new wheat varieties for sustainable agricultural...

    Agriculture, Agricultural
  • By Wiley   -   Sep 23, 2020

    THE GENOME OF CLEISTOGENES SONGORICA PROVIDES A BLUEPRINT FOR FUNCTIONAL DISSECTION OF DIMORPHIC FLOWER DIFFERENTIATION AND DROUGHT ADAPTABILITY

    Summary Cleistogenes songorica is a desert grass with a unique dimorphic flowering mechanism and an ability to survive extreme drought....

    Genomics, Genetics, Biosynthesis, Genome, Chromosomes, Gene, Genes
  • By Wiley   -   Sep 23, 2020

    STUDYING DYNAMICS WITHOUT EXPLICIT DYNAMICS: A STRUCTURE‐BASED STUDY OF THE EXPORT MECHANISM BY ACRB

    Abstract RND family proteins are transmembrane proteins identified as large spectrum drug transporters involved in multi‐drug resistance....

    Protein, Drug, Drugs, Antibiotics
  • By Wiley   -   Sep 21, 2020

    OVEREXPRESSION OF A PLASMA MEMBRANE PROTEIN GENERATED BROAD‐SPECTRUM IMMUNITY IN SOYBEAN

    Abstract Plants fight‐off pathogens and pests by manifesting an array of defense responses using their innate immunity mechanisms....

    Plants, Amino acids, Protein, Gene, Immunity, Genes
  • By Wiley   -   Sep 19, 2020

    GENOMIC ANALYSES OF DIVERSE WILD AND CULTIVATED ACCESSIONS PROVIDE INSIGHTS INTO THE EVOLUTIONARY HISTORY OF JUJUBE

    Summary The Chinese jujube , a member of the Rhamnaceae family, is an important perennial fruit tree crop of substantial economic,...

    Polymorphisms, Medicine, Genome, Genomics, Genes, Gene, Genetics